Diagnostic techniques for monitoring physical devices and resolving operational events

Operational events associated with a target physical device can be detected for mitigation by implementing some aspects described herein. For example, a system can apply a sliding window to received sensor measurements at successive time intervals to generate a set of data windows. The system can determine a set of eigenvectors associated with the set of data windows by performing principal component analysis on a set of data points in the set of data windows. The system can determine a set of angle changes between pairs of eigenvectors. The system can generate a measurement profile by executing an integral transform on the set of angle changes. One or more trained machine-learning models are configured to detect an operational event associated with the target physical device based on the measurement profile and generate an output indicating the operational event.