6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound:Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (P...
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| creator | Brehmer, Dirk Lawson, Edward Charles Boeckx, An Diels, Gaston Stanislas Marcella Wu, Tongfei Meerpoel, Lieven Beke, Lijs Thuring, Johannes Wilhelmus John F Gilissen, Ronaldus Arnodus Hendrika Joseph Schepens, Wim Bert Griet Viellevoye, Marcel Pande, Vineet Sun, Weimei Paradé, Marcus Cornelis Bernardus Catharina |
| description | Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound:Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5). |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors |
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