6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound:Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (P...

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Bibliographische Detailangaben
Hauptverfasser:	Brehmer, Dirk, Lawson, Edward Charles, Boeckx, An, Diels, Gaston Stanislas Marcella, Wu, Tongfei, Meerpoel, Lieven, Beke, Lijs, Thuring, Johannes Wilhelmus John F, Gilissen, Ronaldus Arnodus Hendrika Joseph, Schepens, Wim Bert Griet, Viellevoye, Marcel, Pande, Vineet, Sun, Weimei, Paradé, Marcus Cornelis Bernardus Catharina
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound:Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).