Valve assembly with sealing capability for instruments and/or guide wires for use as access/tool port

A valve assembly for instruments and/or guide wires for use as access/tool port includes a cannula attached to a valve housing with a through hole. Elastic valve members are housed in the valve housing for sealing the through hole either when no device is inserted, or when a specific device with a compatible cross section is inserted. A further sealing arrangement is housed in the valve housing. The further sealing arrangement is extendable within the valve housing to selectively reduce the width of the through hole from a non-sealed configuration where one generic device or a group of generic devices, not necessarily having the same size and/or shape, can be inserted into and/or removed from the through hole, to a sealed configuration where the sealing arrangement seals the through hole with the generic device or the group of generic devices inserted into the through hole.