(R)-8-(1-((3-fluorophenyl)amino)ethyl)-N-(2-hydroxyethyl)-2-morpholinoquinoxaline-6-carboxamide for inhibiting phosphoinositide-3-kinase activity

(R)-8-(1-((3-fluorophenyl)amino)ethyl)-N-(2-hydroxyethyl)-2-morpholinoquinoxaline-6-carboxamide for inhibiting phosphoinositide-3-kinase activity

The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical composi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Querolle, Olivier Alexis Georges, Meerpoel, Lieven, Berthelot, Didier Jean-Claude, Angibaud, Patrick Rene, Willot, Matthieu Philippe Victor, Jousseaume, Thierry Francois Alain Jean, Meyer, Christophe
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.