Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide

Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide

The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the...

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Hauptverfasser: Fan, Yu, Eastgate, Martin D, Gonzalez-Bobes, Francisco, Hickey, Matthew R, Razler, Thomas M, Aytar, Burcu Selin, Green, Rebecca A, Savage, Scott A, Sfouggatakis, Chris, Leahy, David K, Deerberg, Joerg, La Cruz, Thomas E, Borovika, Alina, Zaretsky, Serge, Zheng, Bin, Fenster, Michael David Bengt, Lauser, Kathleen, Zhu, Ye, Luo, Helen Y, Domagalski, Nathan R, Chan, Collin, Lee, Hong Geun, Soumeillant, Maxime C. D, Kopp, Nathaniel David, Forest, Robert V
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.