Systems and techniques for securely processing disparate data sets in spreadsheets

An aspect of the present teachings generally includes a data processing platform (e.g., a platform hosted by a remote computing resource) that analyzes and compiles information contained in a source spreadsheet, e.g., to ascertain how the source spreadsheet manipulates input data. The data processing platform may create an encrypted file related to the source spreadsheet that includes transformed input data and/or directives that define functionality of the source spreadsheet, e.g., where the encrypted file is specifically tailored for use on the data processing platform for a particular user or set of users. Also, or instead, the data processing platform may create or otherwise utilize one or more runtimes that, when executed in conjunction with the encrypted file, can mimic functionality of the source spreadsheet and/or other useful functionality applied to the input data or other disparate data.