Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors

Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer.

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Bibliographische Detailangaben
Hauptverfasser: Jones, Alison, Stockley, Martin Lee, Woodrow, Michael David, Kemp, Mark Ian
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer.