Methods, systems, and compositions for counting nucleic acid molecules

Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are n...

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Bibliographische Detailangaben
Hauptverfasser: Sekedat, Matthew, Beaubien, Jr., Ronald David, Singh, Sharat, Buis, Jeffrey, Perry, Jeff
Format: Patent
Sprache:eng
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Zusammenfassung:Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.