Cytotoxin and conjugate, uses of same and preparation method therefor

Cytotoxin and conjugate, uses of same and preparation method therefor

Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO...

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Hauptverfasser: Deng, Hanwen, Huang, Haitao, Liu, Dengnian, Tian, Qiang, Xue, Tongtong, Song, Hongmei, Hu, Ruibin, Liu, Liping, Wang, Jing, Xiao, Liang, Song, Shuai, Zhong, Guoqing, Long, Rongrong, Wang, Lichun, Wang, Jingyi, Zeng, Hong, Zhang, Qiang, Cai, Jiaqiang, Tang, Zujian
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.