Hardware-software design flow with high-level synthesis for heterogeneous and programmable devices

For an application specifying a software portion for implementation within a data processing engine (DPE) array of a device and a hardware portion having High-Level Synthesis (HLS) kernels for implementation within programmable logic (PL) of the device, a first interface solution is generated that maps logical resources used by the software portion to hardware resources of an interface block coupling the DPE array and the PL. A connection graph specifying connectivity among the HLS kernels and nodes of the software portion to be implemented in the DPE array; and, a block diagram based on the connection graph and the HLS kernels are generated. The block diagram is synthesizable. An implementation flow is performed on the block diagram based on the first interface solution. The software portion of the application is compiled for implementation in one or more DPEs of the DPE array.