Substituted reverse pyrimidine Bmi-1 inhibitors
Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer medi...
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| creator | Cao, Liangxian Paget, Steven D Davis, Thomas W Baiazitov, Ramil Liu, Ronggang Moon, Young-Choon Sydorenko, Nadiya Wilde, Richard Gerald Lee, Chang-Sun Du, Wu Ren, Hongyu |
| description | Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. |
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| subjects | CHEMISTRY ELECTROTHERAPY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MAGNETOTHERAPY MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RADIATION THERAPY ULTRASOUND THERAPY |
| title | Substituted reverse pyrimidine Bmi-1 inhibitors |
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