Substituted reverse pyrimidine Bmi-1 inhibitors

Substituted reverse pyrimidine Bmi-1 inhibitors

Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer medi...

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Bibliographische Detailangaben
Hauptverfasser: Cao, Liangxian, Paget, Steven D, Davis, Thomas W, Baiazitov, Ramil, Liu, Ronggang, Moon, Young-Choon, Sydorenko, Nadiya, Wilde, Richard Gerald, Lee, Chang-Sun, Du, Wu, Ren, Hongyu
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
ELECTROTHERAPY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
RADIATION THERAPY
ULTRASOUND THERAPY
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Zusammenfassung:Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.