Methods and systems for a single-bolus angiography and perfusion scan

Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon an injection of a contrast agent, performing a plurality of perfusion acquisitions of a first anatomical region of interest (ROI) of a subject with the imaging system, processing projection data of the first anatomical ROI obtained from the plurality of perfusion acquisitions to measure a contrast signal of the contrast agent, performing a plurality of angiography acquisitions, each angiography acquisition performed at a respective time determined based on the contrast signal, and performing one or more additional perfusion acquisitions between each angiography acquisition.