Two dimensional barcode provided with surrounding dynamic environmental indicator and color calibration reference

An indicator includes a substrate, a two-dimensional barcode symbol provided on the substrate, a space on the substrate surrounding the barcode symbol, and a historical environmental condition indicator on the substrate. The two-dimensional barcode symbol may be printed on the substrate, preferably in a rectangular, and more preferably in a square configuration. The two-dimensional barcode is printed preferably in black and white and more preferably according to a certain standard. The space on the substrate surrounding the barcode symbol has four quadrants. Additionally, the historical environmental condition indicator is preferably a historical temperature indicator, which occupies space on the substrate in at least two of the four quadrants. The historical environmental condition indicator preferably occupies three and more preferably occupies four of the four quadrants.