Detecting and managing relocation of network communication endpoints in a distributed computing environment

Techniques for managing communications between applications executing in a distributed computing environment are presented. An example method includes detecting, by a first virtual machine, that an application has migrated from a source virtual machine to a destination virtual machine in the distributed computing environment. The first virtual machine identifies a location of the destination virtual machine in the distributed computing environment. Based on the identified location, the first virtual machine generates one or more routing rules for communications between applications executing on the first virtual machine and the migrated application, wherein the one or more routing rules comprise rules that minimize latency and processing overhead for communications with the migrated application in the distributed computing environment.