Peptide macrocycles against Acinetobacter baumannii

The present invention provides compounds of formula (I)wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising...

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Bibliographische Detailangaben
Hauptverfasser:	Kroll, Carsten, Bleicher, Konrad, Hu, Taishan, Kolczewski, Sabine, Hilpert, Hans, Beignet, Julien, Fasching, Bernhard, Zampaloni, Claudia, Alanine, Alexander, Stoll, Theodor, Thomas, Helmut, MacDonald, Dwight, Shen, Hong, Wahhab, Amal, Jackson, Stephen, Schaeublin, Adrian
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides compounds of formula (I)wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.