Delivery constructs for transcytosis and related methods

The present disclosure provides non-naturally occurring fusion molecules comprising therapeutic cargo moieties, such as IL-22 with a carrier. The disclosure also provides methods and compositions for the production, purification, refolding, formulation, and administration of fusion molecules. Method...

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Bibliographische Detailangaben
Hauptverfasser: Olson, Charles, Mahmood, Tahir, Mrsny, Randall J, Feng, Weijun, Postlethwaite, Sally
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present disclosure provides non-naturally occurring fusion molecules comprising therapeutic cargo moieties, such as IL-22 with a carrier. The disclosure also provides methods and compositions for the production, purification, refolding, formulation, and administration of fusion molecules. Methods and for using the purified molecules to treat and prevent diseases or disorders are also provided herein.