Heteroaromatic compounds and their use as dopamine D1 ligands

Heteroaromatic compounds and their use as dopamine D1 ligands

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brodney, Michael Aaron, Gray, David Lawrence Firman, Lee, Chewah, Henderson, Jaclyn Louise, Mente, Scot Richard, O'Neil, Steven Victor, Rogers, Bruce Nelsen, Efremov, Ivan Viktorovich, Zhang, Lei, Dounay, Amy Beth, Davoren, Jennifer Elizabeth, Green, Michael Eric
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), age-related cognitive decline, dementia, and Parkinson's disease.