Triazolopyridine inhibitors of myeloperoxidase and/or EPX

The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful f...

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Bibliographische Detailangaben
Hauptverfasser:	Dilger, Andrew K, Kick, Ellen K, Shaw, Scott A, Vokits, Benjamin P, Clark, Charles G, Jusuf, Sutjano, Smallheer, Joanne M, Wurtz, Nicholas R, Valente, Meriah Neissel
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.