Synthesis of lactams

Synthesis of lactams

Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC-OR-NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Tavares, Francis Xavier
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC-OR-NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam.