Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula...

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Bibliographische Detailangaben
Hauptverfasser:	Caravella, Justin Andrew, Talbot, Adam Charles, Campbell, Ann-Marie, Buckmelter, Alexandre Joseph, Guerin, David Joseph, Wang, Minghua, Lancia, Jr., David R, Ericsson, Anna, Follows, Bruce, Ioannidis, Stephanos, Schmidt, Darby Rye, Diebold, R. Bruce
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where m, n, X1, X2, R1-R5, R5'and R6are described herein.