Bispecific tetravalent antibodies and methods of making and using thereof

Bispecific tetravalent antibodies and methods of making and using thereof

A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Adamo, Jeffrey B, Mak, Nga Sze Amanda, Kovacevich, Brian R, Chen, Lan, Gao, Zeren, Renshaw, Blair R, Zhuo, Shi, Tan, Phil, Zhu, Yi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.