TRPM8 receptor agonist compounds and uses thereof
The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)-(C6-C14) ar...
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| creator | Genazzani, Armando Tron, Gian Cesare Fernandez Carvajal, Asia Belmonte Martinez, Carlos Gallar Martinez, Juana Ferrer Montiel, Antonio Vicente De La Torre, Roberto Mercalli, Valentina |
| description | The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome. |
| format | Patent |
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The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.</description><language>eng</language><subject>CHEMISTRY ; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER ; ELECTRICITY ; GENERATION ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; INSTALLATION OF ELECTRIC CABLES OR LINES, OR OF COMBINEDOPTICAL AND ELECTRIC CABLES OR LINES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210202&DB=EPODOC&CC=US&NR=10905679B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210202&DB=EPODOC&CC=US&NR=10905679B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Genazzani, Armando</creatorcontrib><creatorcontrib>Tron, Gian Cesare</creatorcontrib><creatorcontrib>Fernandez Carvajal, Asia</creatorcontrib><creatorcontrib>Belmonte Martinez, Carlos</creatorcontrib><creatorcontrib>Gallar Martinez, Juana</creatorcontrib><creatorcontrib>Ferrer Montiel, Antonio Vicente</creatorcontrib><creatorcontrib>De La Torre, Roberto</creatorcontrib><creatorcontrib>Mercalli, Valentina</creatorcontrib><title>TRPM8 receptor agonist compounds and uses thereof</title><description>The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. 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The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY CONVERSION OR DISTRIBUTION OF ELECTRIC POWER ELECTRICITY GENERATION HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INSTALLATION OF ELECTRIC CABLES OR LINES, OR OF COMBINEDOPTICAL AND ELECTRIC CABLES OR LINES MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRPM8 receptor agonist compounds and uses thereof |
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