TRPM8 receptor agonist compounds and uses thereof

TRPM8 receptor agonist compounds and uses thereof

The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)-(C6-C14) ar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Genazzani, Armando, Tron, Gian Cesare, Fernandez Carvajal, Asia, Belmonte Martinez, Carlos, Gallar Martinez, Juana, Ferrer Montiel, Antonio Vicente, De La Torre, Roberto, Mercalli, Valentina
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
ELECTRICITY
GENERATION
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INSTALLATION OF ELECTRIC CABLES OR LINES, OR OF COMBINEDOPTICAL AND ELECTRIC CABLES OR LINES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.