Processes and intermediates for NEP inhibitor synthesis

Processes and intermediates for NEP inhibitor synthesis

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as w...

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Bibliographische Detailangaben
Hauptverfasser: Penn, Gerhard, Sedelmeier, Gottfried, Sedelmeier, Joerg, Mafli, Ives, Venturoni, Francesco, Martin, Benjamin, Kleinbeck-Riniker, Florian Karl
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.