Bruton's tyrosine kinase inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in comb...

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Bibliographische Detailangaben
Hauptverfasser:	Xing, Li, Schnute, Mark Edward, Hughes, Robert Owen, Walker, Daniel Patrick, Devadas, Balekudru, Selness, Shaun Raj, Zapf, Christoph Wolfgang, Wan, Zhao-Kui, Springer, John Robert, Garland, Danny James, Schmidt, Michelle Ann, Han, Seungil, Hockerman, Susan Landis, Grapperhaus, Margaret Lanahan, Saiah, Eddine
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.