Efficient data deduplication leveraging sequential chunks or auxiliary databases

Various aspects for data deduplication in a storage system are provided. For instance, a storage controller may perform operations including receiving a data chunk including a set of data blocks, determining a signature for the data chunk, and comparing the signature and a set of reference signatures to determine a match. Responsive to a match, the operations may further include identifying a reference data chunk including a set of comparison blocks associated with the matched reference signature, performing a deduplication technique on the set of data blocks based on the set of comparison blocks, and identifying a subsequent reference data chunk for an estimated next data chunk based on identification of the reference data chunk and prior to receipt of the next data chunk.