Online dilution for a liquid chromatography system using a sample metering pump

An apparatus for diluting a sample in a liquid chromatography system includes a metering pump, a sample needle and a sample valve. One of the sample valve ports is in fluid communication with the first pump port, a second one of the sample valve ports is in fluid communication with the second pump p...

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Bibliographische Detailangaben
Hauptverfasser:	Auclair, John M, Burnett, Joshua A
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	An apparatus for diluting a sample in a liquid chromatography system includes a metering pump, a sample needle and a sample valve. One of the sample valve ports is in fluid communication with the first pump port, a second one of the sample valve ports is in fluid communication with the second pump port, and a third one of the sample valve ports is in fluid communication with the sample needle. The sample valve can be configured in a first to conduct a solvent to the first pump port and to fluidically terminate the second pump port, and in a second state in which the sample needle is in fluid communication with the second pump port. A merge valve configurable in different states is in fluid communication with the sample valve. The states of the sample valve and merge valve can be controlled to perform online dilution.