Antibody drug conjugates (ADC) that bind to FLT3 proteins

Antibody drug conjugates (ADC) that bind to FLT3 proteins

Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention pr...

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Bibliographische Detailangaben
Hauptverfasser: Avina, Hector, Snyder, Josh, Capo, Linnette, Rudra-Ganguly, Nandini, Moon, Sung Ju, Virata, Cyrus, Liu, Gao, Malik, Faisal Hayat, Lowe, Christine
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.