Systems and methods for autonomous bids of advertisement inventory

Methods and systems are described for providing programmatic bidding of advertisement inventory. In one embodiment, an advertising system includes an ad bidding component or module of an ad server and a storage medium coupled to the ad server. The storage medium stores instructions including instructions of the ad bidding component or module. Processing logic is configured to execute the instructions to receive a bid campaign function call for an ad campaign from an advertising entity, determine objectives for the advertising entity including life time value (LTV) for users and return on investment (ROI) for the ad campaign, determine targeted users having characteristics appropriate for satisfying the objectives of the advertising entity, and autonomously determine a dynamic ad bid price parameter and associated group of targeted users that satisfy the objectives of the advertising entity based on having characteristics that satisfy at least three different parameters.