Self-righting tip cap

A self-righting tip cap includes a cap body having a generally oblate spheroid external shell geometry defining a first end and a second end. The first end has a base surface, and at least one clip extends from the body towards the second end. A coupling element accessible from the second end provides removable attachment of the tip cap to a cooperating coupling of a syringe or other female ENFit connectors. The geometry of the tip cap causes it to tend toward uprighting itself when dropped onto a flat surface, such that the base surface is in contact with the flat surface and the coupling element is accessible in an upward facing orientation. According to example forms, at least one rib of a female coupling can become interengaged with at least a portion of the clips such that the self-righting tip cap can be pulled and/or rotationally moved relative to the female coupling to be removed therefrom.