3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA

3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA

The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gampe, Christian, Yuan, Jun, Williams, Sarah, Cohen, Scott Louis, Barnes-Seeman, David, Zecri, Frederic, Diener, John Louis, White, Amy, Roache, James
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Beschreibung
Zusammenfassung:The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.