Running client experiments based on server-side user segment data

A machine may be configured to assign digital content campaign treatments to targets of a digital content campaign, at a server. For example, the machine access data pertaining to one or more characteristics of an application. The application is hosted on a client device. The data is stored at a server-side database. The machine determines that the one or more characteristics of the application match one or more targeting criteria associated with a digital content campaign. The digital content campaign includes a plurality of flights of a digital content item. The machine assigns a flight of the plurality of flights of the digital content campaign to the client device. The flight identifies a variant of the digital content item. The machine transmits a communication to the client device via a network. The communication includes a flight identifier associated with the flight.