Methods for the preparation of obeticholic acid and derivatives thereof
The present application relates to a method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising direct alkylation of a carbon atom at the C-6 position of 7 keto lithocholic acid (KLCA) with an alkylating agent and reduction of...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The present application relates to a method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising direct alkylation of a carbon atom at the C-6 position of 7 keto lithocholic acid (KLCA) with an alkylating agent and reduction of a keto group at the C-7 position. |
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