Interrupt and message generation independent of status register content

In an example, memory register interrupt based signaling and messaging may include receiving, at a control register of a receiver, a signal number from a sender, and copying, by a memory register interrupt management device of the receiver, the signal number to an associated status register of the receiver. Further, memory register interrupt based signaling and messaging may include generating, independently of the signal number from the status register, an interrupt to a central processing unit of the receiver, and triggering, based on the interrupt, an interrupt handler of the receiver to perform an action associated with the signal number.