5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect

Provided is a compound which is useful as an AMPK activator. A compound represented by formula: wherein R 1 is hydrogen, or substituted or unsubstituted alkyl; R 2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; T is -CR 5 = or -N=; X is a single bond, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; Y is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; Z is R S R S' (O=)S=N-, R S R S' (O=)S=N-R 2f -, R S R S' (O=)S=N-C(=O)-, (R N )N=S(=O)(R S )-, (R N )N=S(=O)(R S )-R 2f -, R S R S' (R N' -N=)S=N-, or the like; n is an integer 1 or 2; R S and R S' are each independently substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or the like; R 2f is substituted or unsubstituted alkylene; R N is each independently hydrogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, or the like; R N' is hydrogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl or the like; and R 3 , R 4 and R 5 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like, or its pharmaceutically acceptable salt.