Method for making a biofabricated material containing collagen fibrils

Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA te...

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Bibliographische Detailangaben
Hauptverfasser: Williamson, David Thomas, Purcell, Brendan Patrick, Schofer, Susan J, Spinella, Stephen M, Congdon, Amy, Marga, Francoise Suzanne, Cassingham, Darryl Miles
Format: Patent
Sprache:eng
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Zusammenfassung:Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.