Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials

Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials

A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Babcock, Walter C, Friesen, Dwayne Thomas, Shanker, Ravi M, Smithey, Daniel Tod, Rabenstein, Mark D, Perlman, Michael E
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.