Fusion proteins for treating cancer and related methods

Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g., EGFRvIII-expressing cells that also express interferon receptors) and that induce anti-proliferative effe...

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Bibliographische Detailangaben
Hauptverfasser: Way, Jeffrey Charles, Robinson-Mosher, Avram Lev
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g., EGFRvIII-expressing cells that also express interferon receptors) and that induce anti-proliferative effects, and related compositions and methods for the treatment of cancer.