Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and β-cell dysfunction

The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or n...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Betz, Ulrich, Braendle, Marian, Beier, Norbert, Scholz, Wolfgang
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of ß-cell compensation.