Pharmaceutical compositions of donepezil having specific in vitro dissolution profile or pharmacokinetics parameters

Pharmaceutical compositions of donepezil having specific in vitro dissolution profile or pharmacokinetics parameters

A timed release pharmaceutical composition comprising donepezil is provided, wherein the composition exhibits the in vitro dissolution profile when tested in a Paddle dissolution apparatus at 50 rpm in 900 ml 6.8 buffer at 37° C., less than about 20% w/w of donepezil is released in 3 to 6 hrs, and m...

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Bibliographische Detailangaben
Hauptverfasser: Bakhle, Dhananjay Sadashiv, Chandran, Sajeev, Deshmukh, Ashish Ashokrao, Shah, Chirag Anilkumar, Gadve, Snehal Ameet, Sharma, Neha
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A timed release pharmaceutical composition comprising donepezil is provided, wherein the composition exhibits the in vitro dissolution profile when tested in a Paddle dissolution apparatus at 50 rpm in 900 ml 6.8 buffer at 37° C., less than about 20% w/w of donepezil is released in 3 to 6 hrs, and more than 90% w/w of donepezil is released after 12 hrs.