Systems and methods for minimizing audio glitches when incurring system management interrupt latency

In accordance with these and other embodiments of the present disclosure, a method may include determining whether a system management interrupt is expected to take more than a predetermined threshold duration to complete, determining whether audio data is actively streaming from a processor of an information handling system to an audio controller communicatively coupled to the processor and configured to process audio data communicated from the processor to the audio controller for reproduction to a speaker communicatively coupled to the audio controller, and executing the system management interrupt if the system management interrupt is expected to take less than a predetermined threshold duration to complete or if audio data is not actively streaming from the processor to the audio controller.