Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)

Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)

The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid ar...

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Bibliographische Detailangaben
Hauptverfasser: Salbo, Rune, Grell, Susanne Nedergaard, Wiberg, Charlotte, Henriksen, Anette, Stennicke, Vibeke Westphal, Read, Christine Brender, Padkjaer, Soeren
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.