Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation method therefor

The present invention relates to a hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor. Specifically, the present invention relates to 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]...

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Bibliographische Detailangaben
Hauptverfasser:	Gao, Xiaohui, Jia, Junlei, Wu, Guaili
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor. Specifically, the present invention relates to 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d] pyrimidin-7(8H)-one hydroxyethyl sulfonate (compound of formula (I)), a crystal type I thereof and a preparation method therefor. Crystal type I of the compound shown in formula (I) obtained by the present invention has good chemical stability and crystalline stability, and has low toxicity and residue with respect to the solvent used for crystallization. Therefore, the crystal type I can be used in clinical therapy better.