Androgen receptor modulating compounds

Androgen receptor modulating compounds

Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vesalainen, Anniina, Koivikko, Pia, Salo, Harri, Holm, Patrik, Törmäkangas, Olli, Karjalainen, Arja, Höglund, Iisa, Rasku, Sirpa, Wohlfahrt, Gerd
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.