Inhibitors of influenza viruses replication

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a c...

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Hauptverfasser: Wannamaker, M. Woods, Gu, Wenxin, Deng, Hongbo, Wang, Tiansheng, Court, John J, Ledeboer, Mark W, Lin, Chao, Ledford, Brian, Bandarage, Upul K, Farmer, Luc J, Duffy, John P, Davies, Ioana, Gao, Huai, Jacobs, Dylan H, Kwong, Ann Dak-Yee, Bethiel, Randy S, Kennedy, Joseph M, Charifson, Paul S, Jones, Steven, Clark, Michael P, Jiang, Min, Perola, Emanuele, Germann, Ursula A, Maltais, Francois, Zhou, Yi, Byrn, Randal, Salituro, Francesco G
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Sprache:eng
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Zusammenfassung:Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.