Triazine compounds as PI3 kinase and mTOR inhibitors

Triazine compounds as PI3 kinase and mTOR inhibitors

and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this inventio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Delos Santos, Efren Guillermo, Zask, Arie, Chen, Zecheng, Richard, David James, Kaplan, Joshua Aaron, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Dehnhardt, Christoph Martin, Verheijen, Jeroen Cunera, Shi, Mengxiao, Gopalsamy, Ariamala, Curran, Kevin Joseph, Venkatesan, Aranapakam Mudumbai, Mansour, Tarek Suhayl
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.