Macrocylic pyrimidine derivatives

Macrocylic pyrimidine derivatives

wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions compr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schoentjes, Bruno, Meerpoel, Lieven, Berthelot, Didier Jean-Claude, Embrechts, Werner Constant Johan, Viellevoye, Marcel, Willems, Marc, Diels, Gaston Stanislas Marcella, Wroblowski, Berthold, Versele, Matthias Luc Aime
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.