Systems and methods for binding a removable cryptoprocessor to an information handling system

In accordance with these and other embodiments of the present disclosure, an information handling system may include a processor and a basic input/output system (BIOS) including a program of instructions. The BIOS may be configured to, when read and executed by the processor, calculate a binding secret for binding a cryptoprocessor to a motherboard of the information handling system, the binding secret based on unique identifying information of both the cryptoprocessor and the motherboard, store the binding secret in a non-volatile memory integral to the cryptoprocessor, and validate binding of the cryptoprocessor to the motherboard by comparing a subsequently-calculated binding secret to the binding secret.